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Omega-3
Bioavailability Study
CoQ10
Specific Benefits
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SPECIFIC HEALTH BENEFITS

Heart Health | Brain Health | Prenatal Health | Children’s Health
Autistic Spectrum Disorders | Joint Health & Mobility | Other| Scientific References

Heart Health Many extensive medical studies show that Omega-3 fish oils
prevent and may improve or reverse atherosclerosis,1-3 angina,4-5 heart attack,4, 6,7 congestive heart failure,8 and arrhythmias;9-11 stabilize heart rhythm;12 and are good for overall heart and cardiovascular health.13-15 Omega-3 also reduces triglycerides 16-18 and is recommended by both The American Heart Association and The National Institutes of Health (NIH). CoQ10 has also been shown to support heart health.*19,20

To keep your heart healthy try Coromega Healthy Heart, which combines both Omega-3 and CoQ10 for ultimate heart health.

 

Brain Health DHA, one of the critical fatty acids in Omega-3, is the essential building block of the brain. DHA comprises over 30% of the fatty acids found in the brain and plays a vital role in how our cells function. Higher levels of DHA have been shown to improve IQ scores, fine motor skills and eye-hand coordination in developing children.21-23 Also, research in the last few years has revealed that diets rich in Omega-3 promote a healthy emotional balance and positive mood,24-27 and may help to maintain a healthy mental status in later years.*28-30

To keep your mind sharp try our original Coromega Omega3 Squeeze.

 

Prenatal Health Omega-3, especially DHA, is crucial for the healthy development of a baby’s brain, eyes, neurological functions and central nervous system during pregnancy.31-34 98% of baby formulas are now fortified with DHA and studies have shown that higher levels of DHA are correlated with cognitive advantage, higher IQ, better attention and better visual function.21,31,34 Additionally, studies have shown that taking DHA during pregnancy helps the mother avoid post partum depression.*27,35,36

To get the high DHA you need during pregnancy and while nursing try Coromega Prenatal OmegaBaby with high DHA

 

Children’s Health Omega-3, especially DHA, is critical to the healthy development of a child’s brain, eyes and heart.21-23 DHA helps to promote overall growth and development.21 Studies have also found that Omega-3 helps children with ADD and ADHD.*37-40

To get your child the high DHA he or she needs try Coromega Child Brain & Body. Multi-vitamins and multi-minerals are crucial to children’s nutrition as well. To give your child the multi-vitamins and minerals he or she needs in a fun and delicious way try Coromega Gummy Fruits!

 

Autistic Spectrum Disorders Supplementation with EPA-rich fish oil has been shown to improve general health, sleep patterns, cognitive and motor skills, concentration, eye contact, sociability and reduce irritability, aggression, and hyperactivity among autistic children.*41,42

We would recommend using our original Coromega Omega3 Squeeze for children with autistic disorders due to the higher EPA. Coromega is gluten/ casein free and contains no carbohydrates, sugar or artificial sweeteners.

 

Joint Health & Mobility Omega-3 fatty acids may block some of the body’s processes that limit joint health and freedom of movement and have been found to reduce stiffness, and pain associated with arthritis as well as inflammation.43-45 More than a dozen studies in the last 10 years have found that a diet with a more balanced intake of Omega-3 to Omega-6 fatty acids may help maintain healthy joints.*46

To keep your joints happy and healthy try our original Coromega Omega3 Squeeze.

 

Other Benefits Many extensive medical studies show that fish oils: prevent and may improve or reverse stroke and peripheral vascular disease,47,48 maintain the elasticity of artery walls,49 prevent blood clotting,1,50 help combat inflammation,51-53 and depression,24-27,54 and reduce blood pressure.3,55 Other Omega-3 research studies suggest positive health benefits for the skin,56,57 lungs,58-60 and other areas when the diet includes servings of foods rich in Omega-3 fatty acids and is combined with other prudent health measures.*

Visit the following web site to learn more: http://www.oilofpisces.com

FDA disclaimer

 

REFERENCES

1. Din, JN, et al. Dietary intervention with oil rich fish reduces platelet-monocyte
aggregation in man. Atherosclerosis, Vol. 197, 2008, pp. 290-96

2. Biscione F. et al. Cardiovascular effects of omega-3 free fatty acids.
Curr Vasc Pharmacol. Vol. 5, April 2007, pp. 163-172.

3. Kris-Etherton, PM, et al. Fish consumption, fish oil, omega-3 fatty acids, and
cardiovascular disease. Circulation, Vol. 106, November 19, 2002, pp. 2747-57

4. Harris, W.S. et al. Blood Omega-3 and Trans Fatty Acids in Middle-Aged Acute
Coronary Syndrome Patients. American Journal of Cardiology, 2007, Vol. 99,
pp. 154-8

5. Salachas, Anastasios, et al. Effects of low-dose fish oil concentrate on angina,
exercise tolerance time, serum triglycerides, and platelet function. Angiology, Vol.
45, December 1994, pp. 1023-31

6. Calder, Philip C. New evidence in support of the cardiovascular benefit of long-chain
n-3 fatty acids. Italian Heart Journal, Vol. 4, July 2003, pp. 427-29

7. Thies, Frank, et al. Association of n-3 polyunsaturated fatty acids with stability of
atherosclerotic plaques: a randomized controlled trial. The Lancet, Vol. 361,
February 8, 2003, pp. 477-85

8. Gissi-HF investigators, Effect of n-3 polyunsaturated fatty acids in patients with
chronic heart failure (the GISSI-HF trial): a randomized, double-blind, placebo-
controlled trial. The Lancet, Vol. 372, October 4, 2008, pp. 1223-30.

9. Metcalf, RG, et al. Effect of dietary n-3 polyunsaturated fatty acids on the
inducibility of ventricular tachycardia in patients with ischemic cardiomyopathy.
American Journal of Cardiology, Vol. 101, 2008, pp. 758-61

10. London, B, et al. Omega-3 fatty acids and cardiac arrhythmias: Prior studies
and recommendations for future research. Circulation, Vol. 116, September 2,
2007, pp. 320-35

11. De Caterina, Raffaele, et al. Antiarrhythmic effects of omega-3 fatty acids:
from epidemiology to bedside. American Heart Journal, Vol. 146, September 2003,
pp. 420-30

12. Mozaffarian, D, et al. Dietary fish and omega-3 fatty acid consumption and heart
rate variability in US adults. Circulation, Vol. 117, March 4, 2008, pp. 1130-37

13. Harris, WS, et al. Omega-3 fatty acids and coronary heart disease risk: clinical
and mechanistic perspectives. Atherosclerosis, Vol. 197, March 2008, pp. 12-24.

14. Wang, C. et al. n-3 Fatty acids from fish or fish-oil supplements, but not alpha-
linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-
prevention studies: a systematic review. The American Journal of Clinical
Nutrition, Vol. 84, July 1, 2006, pp. 5-17

15. Harper, C.R. and Jacobson, T.A. Usefulness of Omega-3 Fatty Acids and the
Prevention of Coronary Heart Disease. American Journal of Cardiology, Vol. 96,
December 2005, pp. 1521-29

16. Skulas-Ray AC, West SG, Davidson MH, Kris-Etherton PM. Omega-3 fatty acid
concentrates in the treatment of moderate hypertriglyceridemia. Expert Opin
Pharmacother 2008 May;9(7):1237-48.

17. Brunton S, Collins N. Differentiating prescription omega-3-acid ethyl esters
(P-OM3) from dietary-supplement omega-3 fatty acids. Curr Med Res Opin 2007
May;23(5):1139-45.

18. Harris, William S. n-3 fatty acids and serum lipoproteins: human studies.
American Journal of Clinical Nutrition, Vol 65 (suppl), 1997, pp. 1645S-54S
[83 references].

19. Langsjoen, PH et al. Overview of the use of CoQ10 in cardiovascular disease.
Biofactors, Vol. 9, 1999, pp.273-84.

20. Molyneux SL, et. Al. Coenzyme Q10: an independent predictor of mortality in
chronic heart failure. J. Am Coll Cardiol. 2008 Oct. 28; 52(18):1435-41

21. Oken E, Osterdal ML, Gillman MW et al. Associations of maternal fish intake during
pregnancy and breastfeeding duration with attainment of developmental mile
stones in early childhood: a study from the Danish National Birth Cohort. Am J
Clin Nutr 2008 September; 88(3):789-96.

22. Innis SM. Dietary omega-3 fatty acids and the developing brain.
Brain Research, October 27, 2008, pp. 35-43.

23. Carlson, S.E. Long-chain polyunsaturated fatty acids and development of human
infants. Acta Paediatr Suppl, No. 430, 1999, pp. 72-7

24. Nemets, Hanah, et al. Omega-3 treatment of childhood depression. American
Journal of Psychiatry, Vol. 163, June 2006, pp. 1098-1100

25. Small, Meredith F. The happy fat. New Scientist, August 24, 2002, pp. 34-37

26. Bruinsma, Kristen A. and Taren, Douglas L. Dieting, essential fatty acid intake, and
depression. Nutrition Reviews, Vol. 58, April 2000, pp. 98-108

27. Freeman, MP, et al. Randomized dose-ranging pilot trial of omega-3 fatty acids for
postpartum depression. Acta Psychiatrica Scandinavica, Vol. 113, January 2006,
pp. 31-35

28. Van Gelder, BM, et al. Fish consumption, n-3 fatty acids, and subsequent 5-y
cognitive decline in elderly men. American Journal of Clinical Nutrition, Vol. 85,
2007, pp. 1142-47

29. Freund-Levi, Y, et al. Omega-3 fatty acid treatment in 174 patients with mild to
moderate Alzheimer disease. Archives of Neurology, Vol. 63, October 2006, pp.
1402-08

30. Morris, MC, et al. Consumption of fish and n-3 fatty acids and risk of incident of
Alzheimer’s disease. Archives of Neurology, Vol. 60, July 2003, pp. 940-46

31. Koletzko B, et al. The roles of long-chain polyunsaturated fatty acids in pregnan
cy, lactation and infancy: review of current knowledge and consensus recommen
dations. Journal of Perinatal Medicine, Vol. 36, pp. 5-14.

32. Judge, MP, et al. Maternal consumption of a docosahexaenoic acid-containing func
tional food during pregnancy. American Journal of Clinical Nutrition, Vol. 85, 2007, pp. 1572-77

33. Dunstan, JA, et al. Cognitive assessment of children at age 2½ years after mater
nal fish oil supplementation in pregnancy. Archives of Disease in Childhood. Fetal
and Neonatal Edition. 2006 December 21 [Epub ahead of print]

34. Helland, Ingrid B., et al. Maternal supplementation with very-long-chain n-3 fatty
acids during pregnancy and lactation augments children’s IQ at 4 years of age.
Pediatrics, Vol. 111, January 2003, pp. 39-44

35. De Vriese, SR, et al. Lowered serum n-3 polyunsaturated fatty acid (PUFA) levels
predict the occurrence of postpartum depression: further evidence that lowered
n-PUFAs are related to major depression. Life Sciences, Vol. 73, 2003, pp. 3181-
87

36. Otto, SJ, et al. Increased risk of postpartum depressive symptoms is associated with slower normalization after pregnancy of the functional docosahexaenoic acid status. Prostaglandins, Leukotrienes and Essential Fatty Acids, Vol. 69, 2003, pp. 237-43

37. Colter AL, Cutler C, Meckling KA. Fatty acid status and behavioural symptoms of Attention Deficit Hyperactivity Disorder in adolescents: A case-control study. Nutr J 2008 February 14;7(1):8

38. Sorgi PJ, Hallowell EM, Hutchins HL, Sears B. Effects of an open-label pilot study with high-dose EPA/DHA concentrates on plasma phospholipids and behavior in children with attention deficit hyperactivity disorder. Nutr J 2007;6:16.

39. Sinn, N. and Bryan, J. Effect of supplementation with polyunsaturated fatty acids and micronutrients on learning and behavior problems associated with child ADHD. Journal of Developmental & Behavioral Pediatrics, Vol. 28, April 2007, pp. 82-91

40. Richardson, AJ. Omega-3 fatty acids in ADHD and related neurodevelopmental disorders. Int Rev Psychiatry, Vol. 18, April 2006, pp. 155-72.

41. Amminger, G. Paul, et al. Omega-3 fatty acids supplementation in children with autism. Biological Psychiatry, Vol. 64, No. 4, February 15, 2007, pp. 551-53

42. Bell, JG, et al. Essential fatty acids and phospholipase A2 in autistic spectrum disorders. Prostaglandins, Leukotrienes and Essential Fatty Acids, Vol. 71, 2004, pp. 201-04

43. Darlington, L. Gail and Stone, Trevor W. Antioxidants and fatty acids in the ame lioration of rheumatoid arthritis and related disorders. British Journal of Nutrition, Vol. 85, March 2001, pp. 251-69

44. Volker, Dianne, et al. Efficacy of fish oil concentrate in the treatment of rheuma toid arthritis. Journal of Rheumatology, Vol. 27, October 2000, pp. 2343-46

45. Cleland, Leslie G. and James, Michael J. Fish oil and rheumatoid arthritis: antiin flammatory and collateral health benefits. Journal of Rheumatology, Vol. 27, Octo- ber 2000, pp. 2305-06 (editorial)

46. Watkins, BA, et al. Omega-3 polyunsaturated fatty acids and skeletal health. Exp Biol Med (Maywood), Vol. 226, June 2001, pp. 485-97.

47. He, K, et al. Fish consumption and risk of stroke in men. Journal of the American Medical Association, Vol. 288, December 25, 2002, pp. 3130-36

48. Iso, Hiroyasu, et al. Intake of fish and omega-3 fatty acids and risk of stroke in women. Journal of the American Medical Association, Vol. 285, January 17, 2001, pp. 304-12

49. Tomiyama. H, et al. Do eicosapentaenoic acid supplements attenuate age-related increases in arterial stiffness in patients with dyslipidemia?: A preliminary study. Hypertension Research, Vol. 28, August 2005, pp. 651-5

50. Bays, HE. Safety considerations with omega-3 fatty acid therapy. American Journal
of Cardiology, Vol. 99, No. 6A, March 19, 2007, pp. 35C-43C

51. Goldberg RJ and Katz J. A meta-analysis of the analgesic effects of omega-3 poly
unsaturated fatty acid supplementation for inflammatory joint pain. Pain, Vol.
129, May 2007, pp. 210-23.

52. Maroon, J.C. et al. Omega-3 Fatty Acids as an Anti-inflammatory: an Alternative to
Nonsteroidal Anti-inflammatory Drugs for Discogenic Pain. Surgical Neurology,
2006, Vol. 65, pp. 326-31

53. Zampelas, A. et al. Fish consumption among healthy adults is associated with de
creased levels of inflammatory markers related to cardiovascular disease: The
ATTICA Study. Journal of the American College of Cardiology, Vol. 46, July 2005,
pp. 120-24

54. Edwards, Rhian, et al. Omega-3 polyunsaturated fatty acid levels in the diet and
in red blood cell membranes of depressed patients. Journal of Affective Disorders,
Vol. 48, 1998, pp. 149-55

55. Toft, Ingrid, et al. Effects of n-3 polyunsaturated fatty acids on glucose homeosta-
sis and blood pressure in essential hypertension. Annals of Internal Medicine, Vol.
123, No. 12, December 15, 1995, pp. 911- 18

56. Segger, D, et al. Supplementation with Eskimo Skin Care improves skin elastic- ity in women. A pilot study. Journal of Dermatological Treatment, Vol. 19, 2008,
pp. 279-83

57. Rubin, MG et al. Acne vulgaris, mental health and omega-3 fatty acids: a report of cases. Lipids in Health and Disease, Vol. 7, October 13, 2008, p. 36.

58. Schwartz, Joel. Role of polyunsaturated fatty acids in lung disease. American
Journal of Clinical Nutrition, Vol. 71 (suppl), January 2000, pp. 393S-96S

59. Shahar, Eyal, et al. Dietary n-3 polyunsaturated fatty acids and smoking-related chronic obstructive pulmonary disease. The New England Journal of Medicine, Vol. 331, No. 4, July 28, 1994, pp. 228- 33

60. Broughton, K. Shane, et al. Reduced asthma symptoms with n-3 fatty acid
ingestion are related to 5- series leukotriene production. American Journal of
Clinical Nutrition, Vol. 65, April 1997, pp. 1011- 17

 

NEWSLETTER REFERENCES

October 2009

  1. Effects of Omega-3 Fatty Acids on Resting Heart Rate, Simopoulos AP. 2007.

  2. Omega-3 Fatty Acids and Athletics. Curr Sports Med Rep. 6:230-6.

  3. Rate Recovery After Exercise, and Heart Rate Variability in Men With Healed Myocardial Infarctions and Depressed Ejection Fractions. The American Journal of Cardiology, 2006 Volume 97, Issue 8, Pages 1127-1130 J. O’Keefe, Jr, H. Abuissa, A. Sastre, D. Steinhaus, W.Harris

February 2010

  1. American Heart Association, Fish and Omega-3 Fatty Acids, http://www.americanheart.org/presenter.jhtml?identifier=4632

  2. GIZZI Prevenzione Trial: Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto miocardico. Lancet 1999;354:447–55.

  3. Singh RB, Wander GS, Rastogi A, et al. Randomized double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction. Cardiovasc Drugs Ther 1998;12:347–53.

  4. Rosenfeldt FL, Haas SJ, Krum H, Hadj A, Ng K, Leong J-Y, Watts GF. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Human Hypertension 21: 297-306, 2007

March 2010

  1. Ahmed W, et al. Low serum 25 (OH) vitamin D levels (<32 ng/mL) are associated with reversible myositis-myalgia in statin-treated patients. Transl Res 2009; 153(1): 11-6.

  2. Burr ML, Fehily AM, Gilbert JF, Rogers S, Holliday RM, Sweetnam PM, Elwood PC, Deadman NM. Effects of changes in fat, fish, and fiber intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet. 1989 Sep 30;2(8666):757-61

  3. Maes M, Christophe A, Delanghe J, et al. Lowered omega3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients. Psychiatry Res 1999;85:275-91

  4. Richardson AJ, Puri BK. A randomized double-blind, placebo-controlled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficulties. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Feb;26(2):233-9

  5. Harel Z, Biro FM, Kottenhahn RK, Rosenthal SL. Supplementation with omega-3
    polyunsaturated fatty acids in the management of dysmenorrhea in adolescents. Am J Obstet Gynecol 1996;174:1335-8

  6. Linden KG, Weinstein GD. Psoriasis: current perspectives with an emphasis on treatment. Am J Med 1999;107:595-605

  7. Munger KL, Zhang SM, O'Reilly E, et al. Vitamin D intake and incidence of multiple sclerosis. Neurology 2004;62:60-5

  8. Merlino LA, Curtis J, Mikuls TR, et al. Vitamin D intake is inversely associated with rheumatoid arthritis. Arthritis Rheum 2004;50:72-7

  9. Martins D, Wolf M, Pan D, et al. Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States. Arch Intern Med 2007;167:1159-65